G2D2 is home to Eisai’s Neurology Discovery Data Science Core (NDDSC). Members of the NDDSC have the opportunity to perform foundational data science research that impacts Eisai’s entire neurology discovery portfolio across Eisai’s four worldwide discovery sites in the US, the UK, and Japan. The Head of Human Genetics will be a key leader of the NDDSC team and will have specific responsibilities for genetics strategy and execution. While the focus is expected to be on impacting the discovery process, this position will also serve as the subject matter expert for genetics within neurology, providing expert scientific guidance to impact neurology-related translational science, clinical development, commercial, digital, and investment activities across the company.
The Head of Human Genetics will join an existing (and evolving) data science group at G2D2 and will encounter a corporate culture that is very motivated to apply human genetics and other data-driven approaches to R&D at every level of the organization. Given the expanding scope of the group’s operations, the successful candidate will have the opportunity to build out a small team to achieve this goal.
Expand and lead a team of Ph.D. scientists responsible for applying human genetics to impact program and portfolio decision-making across Eisai’s global Neurology Discovery sites. The team is responsible for leveraging human genetics to identify novel targets, biomarkers, indications, potential safety risks, and target patient populations.
Identify, initiate, and execute collaborations with academic, biotech, and other pharma partners to produce insights capable of impacting program and portfolio decision-making.
Communicate the neurology human genetics strategy, project status, and key results to internal and external colleagues from a variety of scientific backgrounds.
Collaborate with colleagues in Clinical Research and engage with CROs to conduct exploratory genomewide genotyping/sequencing and genetic analysis of Eisai’s neurology clinical trials.
Provide human genetics support to local and global stakeholders in Discovery Research, Translational Research, Clinical Research, and Commercial functions.
Collaborate with colleagues in Informatics and IT to assess needs and develop computational resources for conducting genetic analysis and interpretation of results.
Provide consultation advice as needed to Eisai’s digital ecosystem and venture groups.
Publish/present on key findings as appropriate.
D. in Human Genetics or a related discipline.
5-10 years experience in the biopharmaceutical industry applying human genetics to drive drug discovery and development.
Experience as a member or leader of drug discovery project teams and a demonstrated track record of effectively communicating shifts in project strategy suggested by genetics is required. To the extent that it supports effective communication in this area, a background in biology, pharmacology, chemistry, or another related field may be preferred.
Experience collaborating with top research groups worldwide in the genetics of neurological diseases as well as population-scale genetic research is required.
Experience working on genetics of cellular, molecular, and imaging-based biomarkers is highly preferred.
Familiarity with the global vendor landscape for contract research relating to human genetics (genotyping, data curation, etc.) is required.
Familiarity with a variety of therapeutic modalities, including small molecule, ASO, antibody-based therapeutics, gene therapy, etc. is required.
Excellent oral and written communication skills and the ability to function as a productive member of cross-disciplinary teams is required.
Excellent organizational and management skills are required.
The ability to thrive in a flexible, goal-oriented environment is required.
About Eisai Inc.
At Eisai Inc., human health care (hhc) is our goal. We give our first thought to patients and their families, and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to discover and develop innovative therapies to help address unmet medical needs.
Eisai is a fully integrated pharmaceutical business that operates in two global business groups: oncology and neurology (dementia-related diseases and neurodegenerative diseases). Each group functions as an end-to-end global business with discovery, development, and marketing capabilities. Our U.S. headquarters, commercial and clinical development organizations are located in New Jersey; our discovery labs are in Massachusetts and Pennsylvania; and our global demand chain organization resides in Maryland and North Carolina. To learn more about Eisai Inc., please visit us at www.eisai.com/US.
Eisai Center for Genetics Guided Dementia Discovery (G2D2) -
The Eisai Center for Genetics Guided Dementia Discovery (G2D2) is an industry-unique drug discovery biotech with a d...iverse group of passionate, dedicated and collaborative scientists committed to helping eradicate Alzheimer’s disease and other dementias. Recognizing the potential for human genetics, data sciences and precision chemistry to disrupt the drug discovery paradigm, Eisai established G2D2 to accelerate the discovery of innovative therapeutics. G2D2 is committed to accelerating drug discovery premised upon robust insights from human biology, and driving multi-disciplinary team-based progress towards addressing real unmet patient needs.
At G2D2, we focus not only on how such data help identify and validate therapeutic targets, but also to guide novel approaches to drug such targets and match them to the right patient at the right time. Our precision chemistry strategy in the context of insights from human genetics - is uniquely positioned to deliver tailor-designed small molecule, anti-sense oligo-nucleotide, and other solutions for targeted therapeutics.
Our new cutting-edge 50,000-square-foot facility is strategically located in Cambridge, MA, to accelerate collaborations with leading research institutes in this world-class biotech hub. Our facility has been designed around a novel open-lab concept, enabling chemists, biologists, automation and other scientists to work together in a single common and integrated lab space. Our labs include state-of-the-art capabilities in medicinal and process chemistry, in-vitro and in-vivo biology, microscopy, chemical and structural biology, automation and screening, and several other discovery technologies and platforms.
You will join a highly interactive and collaborative team spanning a broad range of drug discovery capabilities. We highly value both internal and external collaborations, and you will become involved in flexible research models with a range of external scientific partners to accelerate delivery of innovative medicines. As an Eisai employee you will spend at least 1% of your working time with patients and families to ensure that the innovation you drive is based on an understanding of their real needs.
More information about G2D2 is provided here (http://eisai.mediaroom.com/2018-06-12-Eisai-Inc-to-Launch-Center-for-Genetics-Guided-Dementia-Discovery-in-Cambridge-Massachusetts) and here (https://us.eisai.com/research/g2d2), and about Eisai's Neurology strategy and pipeline are provided here (https://www.eisai.com/index.html).